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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AES Antibody (C-term)   

AES Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - AES Antibody (C-term) AP14115b
    Western blot analysis of AES (arrow) using rabbit polyclonal AES Antibody (C-term) (Cat. #AP14115b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the AES gene.
  • WB - AES Antibody (C-term) AP14115b
    AES Antibody (C-term) (Cat. #AP14115b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the AES antibody detected the AES protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q08117
Other Accession NP_001121.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 21970 Da
Antigen Region 156-184 aa
Additional Information
Gene ID 166
Other Names Amino-terminal enhancer of split, Amino enhancer of split, Gp130-associated protein GAM, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, AES, GRG, GRG5
Target/Specificity This AES antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from the C-terminal region of human AES.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAES Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AES
Synonyms GRG, GRG5
Function Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
Cellular Location Nucleus.
Tissue Location Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver
Research Areas
Citations (0)

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The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].


Zhang, Y., et al. Biochem. J. 427(3):499-511(2010)
Beagle, B., et al. PLoS ONE 5 (7), E11821 (2010) :
Arce, L., et al. BMC Cancer 9, 159 (2009) :
Zhang, X., et al. J. Neurosci. Res. 86(11):2423-2431(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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$ 295.00
$ 99.00
Cat# AP14115b
(40 western blots)
Availability: In Stock
Bulk Size
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