|Application ||WB, IHC-P, E|
|Calculated MW||59528 Da|
|Antigen Region||40-69 aa|
|Other Names||Suppressor of cytokine signaling 6, SOCS-6, Cytokine-inducible SH2 protein 4, CIS-4, Suppressor of cytokine signaling 4, SOCS-4, SOCS6, CIS4, SOCS4|
|Target/Specificity||This SOCS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human SOCS6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SOCS6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Choi, Y.B., et al. J. Biol. Chem. 285(10):7271-7280(2010)
Lai, R.H., et al. Gene 448(1):64-73(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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