|Application ||WB, E|
|Other Accession||Q9JHG3, Q9WV08, NP_005152.1|
|Calculated MW||42660 Da|
|Antigen Region||215-244 aa|
|Other Names||Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11, APLNR, AGTRL1, APJ|
|Target/Specificity||This APLNR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the Central region of human APLNR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APLNR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
Tao, Y., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4237-4242(2010)
Zhao, Q., et al. Am. J. Hypertens. 23(6):606-613(2010)
Lee, D.K., et al. Biochem. Biophys. Res. Commun. 395(2):185-189(2010)
Falcao-Pires, I., et al. Expert Opin. Ther. Targets 14(3):231-241(2010)
Peltonen, T., et al. J. Heart Valve Dis. 18(6):644-652(2009)
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