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AKR1B10 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP14125c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP14125c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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AKR1B10 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | O60218 |
| Other Accession | NP_064695.3 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 36020 Da |
AKR1B10 Antibody (Center) - Additional info | |
| Gene ID 57016 | |
| Other Names AKR1B10; AKR1B11; Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein; Small intestine reductase | |
| Target/Specificity This AKR1B10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-130 amino acids from the Central region of human AKR1B10. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AKR1B10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AKR1B10 Antibody (Center) - Protein Information | |
| Name AKR1B10 | |
| Synonyms AKR1B11 | |
| Function Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | |
| Cellular Location Lysosome. Secreted. Note=Secreted through a lysosome-mediated non-classical pathway | |
| Tissue Location Found in many tissues. Highly expressed in small intestine, colon and adrenal gland | |
AKR1B10 Antibody (Center) - Related products
AP14125c: AKR1B10 Antibody (Center)
RI10209: AKR1B10 predesign siRNA
DC02512: Human AKR1B10 cDNA Clone
AT1091a: AKR1B10 Antibody (monoclonal) (M01)
AKR1B10 Antibody (Center) - Application data
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AKR1B10 Antibody (Center) (Cat. #AP14125c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the AKR1B10 antibody detected the AKR1B10 protein (arrow).
AKR1B10 Antibody (Center) - Research Areas
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BACKGROUND
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
REFERENCES
Bailey, S.D., et al. Diabetes Care (2010) In press : Kropotova, E.S., et al. Mol. Biol. (Mosk.) 44(2):243-250(2010) Heringlake, S., et al. J. Hepatol. 52(2):220-227(2010) Ravindranath, T.M., et al. J. Immunol. 183(12):8128-8137(2009) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
