|Application ||WB, E|
|Calculated MW||36020 Da|
|Antigen Region||101-130 aa|
|Other Names||Aldo-keto reductase family 1 member B10, 111-, ARL-1, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase, AKR1B10, AKR1B11|
|Target/Specificity||This AKR1B10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-130 amino acids from the Central region of human AKR1B10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AKR1B10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.|
|Cellular Location||Lysosome. Secreted. Note=Secreted through a lysosome-mediated non-classical pathway|
|Tissue Location||Found in many tissues. Highly expressed in small intestine, colon and adrenal gland|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Kropotova, E.S., et al. Mol. Biol. (Mosk.) 44(2):243-250(2010)
Heringlake, S., et al. J. Hepatol. 52(2):220-227(2010)
Ravindranath, T.M., et al. J. Immunol. 183(12):8128-8137(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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