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HIC1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q14526 |
| Other Accession | Q9R1Y5, Q90850, NP_001091672.1, NP_006488.2 |
| Reactivity | Human |
| Predicted | Chicken, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 76508 Da |
| Antigen Region | 498-527 aa |
| Gene ID | 3090 |
|---|---|
| Other Names | Hypermethylated in cancer 1 protein, Hic-1, Zinc finger and BTB domain-containing protein 29, HIC1, ZBTB29 |
| Target/Specificity | This HIC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-527 amino acids from the C-terminal region of human HIC1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HIC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HIC1 |
|---|---|
| Synonyms | ZBTB29 |
| Function | Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5- [CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down- regulation of SIRT1 and thereby is involved in regulation of p53/TP53- dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis and ovary. Expression is absent or decreased in many tumor cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants.
References
Pehlivan, S., et al. Cancer Genet. Cytogenet. 201(2):128-132(2010)
Van Rechem, C., et al. Mol. Cell. Biol. 30(16):4045-4059(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Zhang, B., et al. Mol. Endocrinol. 23(12):2075-2085(2009)
Tseng, R.C., et al. Neoplasia 11(8):763-770(2009)
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