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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TRAP1 Antibody (C-term)   

TRAP1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TRAP1 Antibody (C-term) AP14128b
    TRAP1 Antibody (C-term) (Cat. #AP14128b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TRAP1 antibody detected the TRAP1 protein (arrow).
  • IHC-P - TRAP1 Antibody (C-term) AP14128b
    TRAP1 Antibody (C-term) (AP14128b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRAP1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q12931
Other Accession NP_057376.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 80110 Da
Antigen Region 542-570 aa
Additional Information
Gene ID 10131
Other Names Heat shock protein 75 kDa, mitochondrial, HSP 75, TNFR-associated protein 1, Tumor necrosis factor type 1 receptor-associated protein, TRAP-1, TRAP1, HSP75
Target/Specificity This TRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 542-570 amino acids from the C-terminal region of human TRAP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRAP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRAP1
Synonyms HSP75
Function Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Cellular Location Mitochondrion. Mitochondrion inner membrane Mitochondrion matrix
Tissue Location Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.
Research Areas
Citations (0)

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HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. TRAP1 is a mitochondrial HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and endoplasmic reticulum (HSP90B1; MIM 191175) (Chen et al., 2005 [PubMed 16269234]).


Liu, D., et al. Cancer Lett. 296(2):194-205(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Nguyen, M.C., et al. Cancer Immunol. Immunother. 59(9):1313-1323(2010)
Landriscina, M., et al. Cancer Res. 70(16):6577-6586(2010)
Leav, I., et al. Am. J. Pathol. 176(1):393-401(2010)

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$ 295.00
$ 99.00
Cat# AP14128b
(40 western blots)
Availability: In Stock
Bulk Size
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