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RPH3A Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RPH3A Antibody (C-term) AP14129b
    RPH3A Antibody (C-term) (Cat. #AP14129b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the RPH3A antibody detected the RPH3A protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y2J0
Other Accession P47709, P47708, Q06846, NP_001137326.1, NP_055769.2
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 76872 Da
Antigen Region 658-686 aa
Additional Information
Gene ID 22895
Other Names Rabphilin-3A, Exophilin-1, RPH3A, KIAA0985
Target/Specificity This RPH3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 658-686 amino acids from the C-terminal region of human RPH3A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRPH3A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RPH3A
Synonyms KIAA0985
Function Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP- dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity).
Cellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P47709}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P47709}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P47709}. Membrane {ECO:0000250|UniProtKB:P47709}; Peripheral membrane protein {ECO:0000250|UniProtKB:P47709}
Research Areas
Citations (0)
citation

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Background

Exocytosis of neurotransmitters and hormones is fundamental to synaptic neurotransmission and cell-cell communication. RAB3A (MIM 179390) is a small G protein that is thought to act at late stages of exocytosis, and RPH3A is a RAB3A effector (Lin et al., 2007 [PubMed 17149709]).

References

Katkoori, V.R., et al. Front. Biosci. 13, 1050-1061 (2008) :
Smith, R., et al. J. Neurochem. 103(1):115-123(2007)
Lin, C.C., et al. J. Cell. Physiol. 211(2):316-326(2007)
Dalfo, E., et al. Neurobiol. Dis. 16(1):92-97(2004)
Rastaldi, M.P., et al. Am. J. Pathol. 163(3):889-899(2003)

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$ 182.50
$ 70.00
Cat# AP14129b
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