|Application ||WB, E|
|Other Accession||P47709, P47708, Q06846, NP_001137326.1, NP_055769.2|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||76872 Da|
|Antigen Region||658-686 aa|
|Other Names||Rabphilin-3A, Exophilin-1, RPH3A, KIAA0985|
|Target/Specificity||This RPH3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 658-686 amino acids from the C-terminal region of human RPH3A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RPH3A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity).|
|Cellular Location||Cell junction, synapse. Membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Exocytosis of neurotransmitters and hormones is fundamental to synaptic neurotransmission and cell-cell communication. RAB3A (MIM 179390) is a small G protein that is thought to act at late stages of exocytosis, and RPH3A is a RAB3A effector (Lin et al., 2007 [PubMed 17149709]).
Katkoori, V.R., et al. Front. Biosci. 13, 1050-1061 (2008) :
Smith, R., et al. J. Neurochem. 103(1):115-123(2007)
Lin, C.C., et al. J. Cell. Physiol. 211(2):316-326(2007)
Dalfo, E., et al. Neurobiol. Dis. 16(1):92-97(2004)
Rastaldi, M.P., et al. Am. J. Pathol. 163(3):889-899(2003)
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