|Application ||WB, IHC-P, E|
|Calculated MW||38518 Da|
|Antigen Region||294-323 aa|
|Other Names||Y-box-binding protein 2, Contrin, DNA-binding protein C, Dbpc, Germ cell-specific Y-box-binding protein, MSY2 homolog, YBX2, CSDA3, MSY2|
|Target/Specificity||This YBX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the C-terminal region of human YBX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||YBX2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
YBX2 is a major constituent of messenger ribonucleoprotein particles (mRNPs). It is nvolved in the regulation of the stability and/or translation of germ cell mRNAs. It binds to Y-box consensus promoter element and to full length mRNA with high affinity in a sequence-independent manner. It binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. YBX2 may mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay.
Kohno,Y., Br. J. Cancer 94 (5), 710-716 (2006)
Yoshida,T., Biochim. Biophys. Acta 1759 (1-2), 80-88 (2006)
Tekur,S., J. Androl. 20 (1), 135-144 (1999)
Gu,W., Biol. Reprod. 59 (5), 1266-1274 (1998)
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