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WNT3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P56703 |
| Other Accession | P17553, P31285, P27467, P56704, Q2LMP1, NP_110380.1 |
| Reactivity | Human |
| Predicted | Chicken, Mouse, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39645 Da |
| Antigen Region | 155-184 aa |
| Gene ID | 7473 |
|---|---|
| Other Names | Proto-oncogene Wnt-3, Proto-oncogene Int-4 homolog, WNT3, INT4 |
| Target/Specificity | This WNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-184 amino acids from the Central region of human WNT3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | WNT3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WNT3 |
|---|---|
| Synonyms | INT4 |
| Function | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406). |
| Cellular Location | Secreted, extracellular space, extracellular matrix. Secreted |
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Provided below are standard protocols that you may find useful for product applications.
Background
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.
References
Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Memarian, A., et al. Leuk. Lymphoma 50(12):2061-2070(2009)
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