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SPN/CD43 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP14144a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP14144a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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SPN/CD43 Antibody (N-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | P16150 |
| Other Accession | NP_001025459.1, NP_003114.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 40322 Da |
SPN/CD43 Antibody (N-term) - Additional info | |
| Gene ID 6693 | |
| Other Names SPN; CD43; Leukosialin; Galactoglycoprotein; Leukocyte sialoglycoprotein; Sialophorin; CD_antigen=CD43; Flags: Precursor | |
| Target/Specificity This SPN/CD43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-60 amino acids from the N-terminal region of human SPN/CD43. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SPN/CD43 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
SPN/CD43 Antibody (N-term) - Protein Information | |
| Name SPN | |
| Synonyms CD43 | |
| Function One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity) | |
| Cellular Location Membrane; Single-pass type I membrane protein | |
| Tissue Location Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas | |
SPN/CD43 Antibody (N-term) - Related products
AM2012a: SPN/CD43 Antibody (N-term)(Ascites)
AM2012b: SPN/CD43 Antibody (N-term)
AP13717a: SPN Antibody (N-term)
AP14085c: SPN/CD43 Antibody (Center)
AP14144a: SPN/CD43 Antibody (N-term)
AP9623c: SPN Antibody (Center)
LY12834a: SPN Over-expression Lysate
SPN/CD43 Antibody (N-term) - Application data
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SPN/CD43 Antibody (N-term) (Cat. #AP14144a) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the SPN/CD43 antibody detected the SPN/CD43 protein (arrow).
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SPN/CD43 Antibody (N-term) (AP14144a)immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SPN/CD43 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
SPN/CD43 Antibody (N-term) - Research Areas
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BACKGROUND
Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.
REFERENCES
Urano-Tashiro, Y., et al. Infect. Immun. 76(10):4686-4691(2008) Mambole, A., et al. J. Biol. Chem. 283(35):23627-23635(2008) Seethala, R.R., et al. Appl. Immunohistochem. Mol. Morphol. 16(2):165-172(2008) Khunkaewla, P., et al. Mol. Immunol. 45(6):1703-1711(2008) Rawal, A., et al. Arch. Pathol. Lab. Med. 131(11):1673-1678(2007)
