|Application ||WB, E|
|Other Accession||Q62862, Q13163, NP_035970.1|
|Calculated MW||50105 Da|
|Antigen Region||385-412 aa|
|Other Names||Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MAPK/ERK kinase 5, MEK 5, Map2k5, Mek5, Mkk5, Prkmk5|
|Target/Specificity||This Mouse Map2k5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-412 amino acids from the C-terminal region of mouse Map2k5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Map2k5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Mek5, Mkk5, Prkmk5|
|Function||Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.|
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Provided below are standard protocols that you may find useful for product applications.
Map2k5 acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
Spiering, D., et al. J. Biol. Chem. 284(37):24972-24980(2009)
Carter, E.J., et al. J. Cell. Sci. 122 (PT 17), 3104-3112 (2009) :
Sohn, S.J., et al. EMBO J. 27(13):1896-1906(2008)
Shishido, T., et al. Circ. Res. 102(11):1416-1425(2008)
Nakamura, K., et al. Mol. Cell. Biol. 27(12):4566-4577(2007)
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