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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Map2k7 Antibody (Center)   

Mouse Map2k7 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Map2k7 Antibody (Center) AP14155c
    Mouse Map2k7 Antibody (Center) (Cat. #AP14155c) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the Map2k7 antibody detected the Map2k7 protein (arrow).
  • WB - Mouse Map2k7 Antibody (Center) AP14155c
    Mouse Map2k7 Antibody (Center) (Cat. #AP14155c) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Map2k7 antibody detected the Map2k7 protein (arrow).
  • IHC-P - Mouse Map2k7 Antibody (Center) AP14155c
    Mouse Map2k7 Antibody (Center) (AP14155c)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Map2k7 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8CE90
Other Accession Q4KSH7, O14733, NP_001157644.1, NP_001036022.1
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 59312 Da
Antigen Region 206-233 aa
Additional Information
Gene ID 26400
Other Names Dual specificity mitogen-activated protein kinase kinase 7, MAP kinase kinase 7, MAPKK 7, JNK-activating kinase 2, MAPK/ERK kinase 7, MEK 7, c-Jun N-terminal kinase kinase 2, JNK kinase 2, JNKK 2, Map2k7 {ECO:0000312|MGI:MGI:1346871}
Target/Specificity This Mouse Map2k7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-233 amino acids from the Central region of mouse Map2k7.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Map2k7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Map2k7 {ECO:0000312|MGI:MGI:1346871}
Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Cellular Location Nucleus. Cytoplasm
Tissue Location Expressed at high levels in brain, lung, liver, skeletal muscle, kidney, and testis and at lower levels in the heart and spleen.
Research Areas
Citations (0)

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Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.


Bogani, D., et al. PLoS Biol. 7 (9), E1000196 (2009) :
Derradji, H., et al. Dev. Biol. 322(2):302-313(2008)
Nishitai, G., et al. J. Cell. Biochem. 104(5):1771-1780(2008)
Wang, X., et al. Mol. Cell. Biol. 27(22):7935-7946(2007)
Jaeschke, A., et al. Mol. Cell 27(3):498-508(2007)

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$ 295.00
$ 99.00
Cat# AP14155c
(40 western blots)
Availability: In Stock
Bulk Size
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