|Application ||WB, IHC-P, E|
|Calculated MW||110112 Da|
|Antigen Region||566-593 aa|
|Other Names||Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4, Mlk4, Kiaa1804|
|Target/Specificity||This Mouse Mlk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 566-593 amino acids from the Central region of mouse Mlk4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Mlk4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Mlk4 activates the JUN N-terminal pathway (By similarity).
Katayama, S., et al. Science 309(5740):1564-1566(2005)
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