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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Pxk Antibody (Center)   

Mouse Pxk Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Pxk Antibody (Center) AP14159c
    Mouse Pxk Antibody (Center) (Cat. #AP14159c) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the Pxk antibody detected the Pxk protein (arrow).
  • WB - Mouse Pxk Antibody (Center) AP14159c
    Western blot analysis of Pxk (arrow) using rabbit polyclonal Mouse Pxk Antibody (Center) (Cat. #AP14159c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Pxk gene.
  • WB - Mouse Pxk Antibody (Center) AP14159c
    Mouse Pxk Antibody (Center) (Cat. #AP14159c) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Pxk antibody detected the Pxk protein (arrow).
  • IHC-P - Mouse Pxk Antibody (Center) AP14159c
    Mouse Pxk Antibody (Center) (AP14159c)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Pxk Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8BX57
Other Accession Q4FZZ1, Q7Z7A4, NP_663433.2, NP_840063.1, Q32NE9
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 65231 Da
Antigen Region 164-193 aa
Additional Information
Gene ID 218699
Other Names PX domain-containing protein kinase-like protein, Modulator of Na, K-ATPase, MONaKA, Pxk {ECO:0000312|MGI:MGI:1289230}
Target/Specificity This Mouse Pxk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-193 amino acids from the Central region of mouse Pxk.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Pxk Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Pxk {ECO:0000312|MGI:MGI:1289230}
Function Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also associates with the plasma membrane
Tissue Location Isoform 1 is present in all tissues examined. Isoform 2 is found in all tissues except skeletal muscle and very low levels in spleen. Both isoforms are widely expressed throughout the nervous system however levels of isoform 2 are higher in purified hippocampal and cortical neurons whereas glial cells express more isoform 1 than isoform 2
Research Areas
Citations (0)

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Background

Pxk binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.

References

Mao, H., et al. J. Neurosci. 25(35):7934-7943(2005)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)

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$ 295.00
$ 99.00
Cat# AP14159c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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