|Application ||WB, E|
|Other Accession||P62069, A5WWB0, NP_001127695.1, NP_073743.2|
|Calculated MW||42442 Da|
|Antigen Region||241-269 aa|
|Other Names||Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46, USP46|
|Target/Specificity||This UBP46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-269 amino acids from the C-terminal region of human UBP46.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UBP46 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.|
|Tissue Location||Broadly expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).
Kushima, I., et al. J. Hum. Genet. 55(3):133-136(2010)
Cohn, M.A., et al. J. Biol. Chem. 284(8):5343-5351(2009)
Zemunik, T., et al. Croat. Med. J. 50(1):23-33(2009)
Quesada, V., et al. Biochem. Biophys. Res. Commun. 314(1):54-62(2004)
Puente, X.S., et al. Nat. Rev. Genet. 4(7):544-558(2003)
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