- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||102032 Da|
|Antigen Region||137-167 aa|
|Other Names||Chordin, CHRD|
|Target/Specificity||This CHRD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-167 amino acids from the N-terminal region of human CHRD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHRD Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).|
|Tissue Location||Expressed at the highest level in liver.|
Provided below are standard protocols that you may find useful for product applications.
CHRD is a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. This protein may also have roles in organogenesis and during adulthood.
Lim,J., Cell 125 (4), 801-814 (2006)
Moll,F., FASEB J. 20 (2), 240-250 (2006)
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