|Application ||WB, E|
|Other Accession||NP_951058.1, NP_060119.3|
|Calculated MW||96623 Da|
|Antigen Region||646-674 aa|
|Other Names||Metal transporter CNNM2, Ancient conserved domain-containing protein 2, Cyclin-M2, CNNM2, ACDP2|
|Target/Specificity||This CNNM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 646-674 amino acids from the C-terminal region of human CNNM2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNNM2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick ascending limb of Henle loop|
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Provided below are standard protocols that you may find useful for product applications.
CNNM2 is a divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Takeuchi, F., et al. Circulation 121(21):2302-2309(2010)
Yasuno, K., et al. Nat. Genet. 42(5):420-425(2010)
Simon-Sanchez, J., et al. Nat. Genet. 41(12):1308-1312(2009)
Newton-Cheh, C., et al. Nat. Genet. 41(6):666-676(2009)
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