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CIR Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - CIR Antibody (C-term) AP1417b
    Western blot analysis of lysate from human placenta tissue lysate, using CIR Antibody (C-term)(Cat. #AP1417b). AP1417b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86X95
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 52313 Da
Antigen Region 396-424 aa
Additional Information
Gene ID 9541
Other Names Corepressor interacting with RBPJ 1, CBF1-interacting corepressor, Recepin, CIR1, CIR
Target/Specificity This CIR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-424 amino acids from the C-terminal region of human CIR.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCIR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CIR1
Synonyms CIR
Function May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Cellular Location Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome
Tissue Location Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.
Research Areas
Citations (0)

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CIR may modulate splice site selection during alternative splicing of pre-mRNAs. It regulates transcription and acts as corepressor for RBPSUH. It recruits RBPSUH to the Sin3-histone deacetylase complex (HDAC), and is required for RBPSUH-mediated repression of transcription.


Olsen,J.V., Cell 127 (3), 635-648 (2006)
Maita,H., Exp. Cell Res. 303 (2), 375-387 (2005)
Zhou,S., Mol. Cell. Biol. 21 (18), 6222-6232 (2001)

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$ 295.00
$ 99.00
Cat# AP1417b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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