|Application ||WB, IHC-P, E|
|Calculated MW||50288 Da|
|Antigen Region||95-124 aa|
|Other Names||Thyroid receptor-interacting protein 6, TR-interacting protein 6, TRIP-6, Opa-interacting protein 1, OIP-1, Zyxin-related protein 1, ZRP-1, TRIP6, OIP1|
|Target/Specificity||This TRIP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the N-terminal region of human TRIP6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIP6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm|
|Tissue Location||Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Shanmugarajan, S., et al. J. Cell. Biochem. 107(1):104-111(2009)
Chastre, E., et al. FASEB J. 23(3):916-928(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Shanmugarajan, S., et al. J. Cell. Biochem. 104(4):1500-1508(2008)
Bai, C.Y., et al. J. Cell. Sci. 120 (PT 16), 2828-2837 (2007) :
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