TRIP6 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q15654 |
Other Accession | NP_003293.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 50288 Da |
Antigen Region | 95-124 aa |
Gene ID | 7205 |
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Other Names | Thyroid receptor-interacting protein 6, TR-interacting protein 6, TRIP-6, Opa-interacting protein 1, OIP-1, Zyxin-related protein 1, ZRP-1, TRIP6, OIP1 |
Target/Specificity | This TRIP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the N-terminal region of human TRIP6. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TRIP6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TRIP6 |
---|---|
Synonyms | OIP1 |
Function | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF- kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. |
Cellular Location | Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm Note=Shuttles between nucleus and cytoplasm (PubMed:16624523) Colocalizes with actin (PubMed:10826496). |
Tissue Location | Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors |
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Background
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
References
Shanmugarajan, S., et al. J. Cell. Biochem. 107(1):104-111(2009)
Chastre, E., et al. FASEB J. 23(3):916-928(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Shanmugarajan, S., et al. J. Cell. Biochem. 104(4):1500-1508(2008)
Bai, C.Y., et al. J. Cell. Sci. 120 (PT 16), 2828-2837 (2007) :
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