|Application ||WB, E|
|Other Accession||P97694, Q9QX11, NP_004753.1, NP_059430.2|
|Calculated MW||46413 Da|
|Antigen Region||37-65 aa|
|Other Names||Cytohesin-1, PH, SEC7 and coiled-coil domain-containing protein 1, SEC7 homolog B2-1, CYTH1, D17S811E, PSCD1|
|Target/Specificity||This CYTH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human CYTH1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYTH1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.|
|Cellular Location||Cell membrane; Peripheral membrane protein Cytoplasm, cytosol|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2.
El Azreq, M.A., et al. J. Immunol. 184(2):637-649(2010)
Quast, T., et al. Blood 113(23):5801-5810(2009)
Sendide, K., et al. J. Immunol. 174(7):4210-4219(2005)
Boehm, T., et al. EMBO J. 22(5):1014-1024(2003)
Mansour, M., et al. J. Biol. Chem. 277(35):32302-32309(2002)
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