|Application ||WB, E|
|Other Accession||P43244, Q8K310, NP_954659.1, NP_001181883.1|
|Calculated MW||94623 Da|
|Antigen Region||157-186 aa|
|Other Names||Matrin-3, MATR3, KIAA0723|
|Target/Specificity||This MATR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-186 amino acids from the N-terminal region of human MATR3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MATR3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.|
|Cellular Location||Nucleus matrix.|
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Provided below are standard protocols that you may find useful for product applications.
This locus encodes a nuclear matrix protein. Mutations at this locus have been associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts with an upstream locus have been described. Related pseuodgenses have been defined on chr1 and chrX.
Zeitz, M.J., et al. J. Cell. Biochem. 108(1):125-133(2009)
Senderek, J., et al. Am. J. Hum. Genet. 84(4):511-518(2009)
Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) :
Malyavantham, K.S., et al. J. Cell. Biochem. 105(2):391-403(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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