MATR3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P43243 |
Other Accession | P43244, Q8K310, NP_954659.1, NP_001181883.1 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 94623 Da |
Antigen Region | 157-186 aa |
Gene ID | 9782 |
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Other Names | Matrin-3, MATR3, KIAA0723 |
Target/Specificity | This MATR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-186 amino acids from the N-terminal region of human MATR3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MATR3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MATR3 |
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Synonyms | KIAA0723 |
Function | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). |
Cellular Location | Nucleus matrix. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This locus encodes a nuclear matrix protein. Mutations at this locus have been associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts with an upstream locus have been described. Related pseuodgenses have been defined on chr1 and chrX.
References
Zeitz, M.J., et al. J. Cell. Biochem. 108(1):125-133(2009)
Senderek, J., et al. Am. J. Hum. Genet. 84(4):511-518(2009)
Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) :
Malyavantham, K.S., et al. J. Cell. Biochem. 105(2):391-403(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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