|Application ||WB, IHC-P, E|
|Calculated MW||61439 Da|
|Antigen Region||514-542 aa|
|Other Names||Zinc finger and BTB domain-containing protein 7A, Factor binding IST protein 1, FBI-1, Factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor, POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21, TIP21, Zinc finger protein 857A, ZBTB7A, FBI1, LRF, ZBTB7, ZNF857A|
|Target/Specificity||This ZBTB7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 514-542 amino acids from the C-terminal region of human ZBTB7A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZBTB7A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FBI1, LRF, ZBTB7, ZNF857A|
|Function||Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).|
|Tissue Location||Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
ZBTB7A plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).
Qu, H., et al. Cancer Invest. 28(6):672-678(2010)
Zu, X., et al. Cell. Mol. Biol. Lett. 15(2):260-271(2010)
Cui, J., et al. Mol. Biol. Rep. 37(3):1627-1632(2010)
Choi, W.I., et al. J. Biol. Chem. 284(19):12633-12644(2009)
Choi, W.I., et al. Cell. Physiol. Biochem. 23 (4-6), 359-370 (2009) :
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