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TMC6 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q7Z403 |
| Other Accession | NP_009198.4, NP_001120670.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 90045 Da |
| Antigen Region | 160-188 aa |
| Gene ID | 11322 |
|---|---|
| Other Names | Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1, Protein LAK-4, TMC6, EVER1, EVIN1 |
| Target/Specificity | This TMC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-188 amino acids from the N-terminal region of human TMC6. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TMC6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMC6 |
|---|---|
| Synonyms | EVER1, EVIN1 |
| Function | Probable ion channel. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes {ECO:0000269|PubMed:12906855, ECO:0000269|Ref.3} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs.
References
McDermott, D.F., et al. Pediatr Dermatol 26(3):306-310(2009)
Lazarczyk, M., et al. J. Exp. Med. 205(1):35-42(2008)
Zuo, Y.G., et al. J. Dermatol. Sci. 44(3):153-159(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Donfack, J., et al. Int. J. Pediatr. Otorhinolaryngol. 70(7):1235-1240(2006)
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