|Application ||WB, E|
|Other Accession||Q5IFK1, NP_078872.2, NP_001166045.1|
|Calculated MW||92877 Da|
|Antigen Region||104-133 aa|
|Other Names||Microcephalin, MCPH1|
|Target/Specificity||This MCPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the N-terminal region of human MCPH1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MCPH1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome|
|Tissue Location||Expressed in fetal brain, liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described.
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Wang, Y.Q., et al. Hum. Mol. Genet. 13(11):1131-1137(2004)
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