|Application ||WB, IHC-P, E|
|Calculated MW||12248 Da|
|Antigen Region||71-100 aa|
|Other Names||C-C motif chemokine 15, Chemokine CC-2, HCC-2, Leukotactin-1, LKN-1, MIP-1 delta, Macrophage inflammatory protein 5, MIP-5, Mrp-2b, NCC-3, Small-inducible cytokine A15, CCL15(22-92), CCL15(25-92), CCL15(29-92), CCL15, MIP5, NCC3, SCYA15|
|Target/Specificity||This CCL15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the C-terminal region of human CCL15.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCL15 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MIP5, NCC3, SCYA15|
|Function||Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.|
|Tissue Location||Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients|
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Provided below are standard protocols that you may find useful for product applications.
This gene, chemokine (C-C motif) ligand 15, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene is chemotactic for T cells and monocytes and induces N-acetyl-beta-D-glucosaminidase release in monocytes. It induces changes in intracellular calcium concentration in monocytes and is thought to act through the CCR1 receptor. Read-through transcripts are expressed that include exons from the downstream cytokine gene, chemokine (C-C motif) ligand 14, and are represented as GeneID: 348249.
Kitamura, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(29):13063-13068(2010)
Cho, J.E., et al. Mol. Cells 29(1):35-39(2010)
Kwon, S.H., et al. Nutr Res Pract 2(2):134-137(2008)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Escher, S.E., et al. J. Pept. Res. 63(1):36-47(2004)
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