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DRAGON (RGMB) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DRAGON (RGMB) Antibody (C-term) AP1421b
    All lanes : Anti-DRAGON (RGMB) Antibody (C-term) at 1:2000 dilution Lane 1: A431 whole cell lysate Lane 2: mouse brain lysate Lane 3: mouse cerebellum lysate Lane 4: NCI-H460 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 48 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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  • WB - DRAGON (RGMB) Antibody (C-term) AP1421b
    Western blot analysis of DRAGON (RGMB) Antibody (C-term) in K562 cell line lysates (35ug/lane). DRAGON (arrow) was detected using the purified Pab.
    detail
  • IHC-P - DRAGON (RGMB) Antibody (C-term) AP1421b
    Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with DRAGON (RGMB) (C-term) (Cat.#AP1421b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q6NW40
Other Accession Q7TQ33
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 47547 Da
Antigen Region 376-406 aa
Additional Information
Gene ID 285704
Other Names RGM domain family member B, DRG11-responsive axonal guidance and outgrowth of neurite, DRAGON, RGMB
Target/Specificity This DRAGON (RGMB) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-406 amino acids from the C-terminal region of human DRAGON (RGMB).
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDRAGON (RGMB) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGMB {ECO:0000303|PubMed:19324014, ECO:0000312|HGNC:HGNC:26896}
Function Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q7TQ33}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q7TQ33}. Membrane raft {ECO:0000250|UniProtKB:Q7TQ33}
Research Areas
Citations (0)
citation

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Background

Repulsive Guidance Molecule B (RGMB) is primarily expressed in the central nervous system. RGM A and B both appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGMA appears in the neuroepithelium, and only RGMB in the peripheral nervous system. During development, both RGMA and B appear also in lung and in limb cartilage, while RGMB has additional expression domains in pancreas.

References

Schnichels,S., Gene Expr. Patterns 8 (1), 1-11 (2007)
Metzger,M., Dev. Dyn. 234 (1), 169-175 (2005)
Xia,Y., Endocrinology 146 (8), 3614-3621 (2005)

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$ 365.00
$ 140.00
Cat# AP1421b
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