|Application ||WB, IHC-P, E|
|Calculated MW||47547 Da|
|Antigen Region||278-309 aa|
|Other Names||RGM domain family member B, DRG11-responsive axonal guidance and outgrowth of neurite, DRAGON, RGMB|
|Target/Specificity||This DRAGON (RGMB) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-309 amino acids from the Central region of human DRAGON (RGMB).|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DRAGON (RGMB) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft|
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Provided below are standard protocols that you may find useful for product applications.
Repulsive Guidance Molecule B (RGMB) is primarily expressed in the central nervous system. RGM A and B both appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGMA appears in the neuroepithelium, and only RGMB in the peripheral nervous system. During development, both RGMA and B appear also in lung and in limb cartilage, while RGMB has additional expression domains in pancreas.
Schnichels,S., Gene Expr. Patterns 8 (1), 1-11 (2007)
Metzger,M., Dev. Dyn. 234 (1), 169-175 (2005)
Xia,Y., Endocrinology 146 (8), 3614-3621 (2005)
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