|Application ||WB, E|
|Calculated MW||52202 Da|
|Antigen Region||406-435 aa|
|Other Names||Neuromedin-K receptor, NKR, NK-3 receptor, NK-3R, Neurokinin B receptor, Tachykinin receptor 3, TACR3, NK3R, TAC3R|
|Target/Specificity||This TACR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 406-435 amino acids from the C-terminal region of human TACR3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TACR3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Gianetti, E., et al. J. Clin. Endocrinol. Metab. 95(6):2857-2867(2010)
Young, J., et al. J. Clin. Endocrinol. Metab. 95(5):2287-2295(2010)
Fukami, M., et al. Horm Res Paediatr 73(6):477-481(2010)
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