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KCND3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - KCND3 Antibody (N-term) AP14226a
    KCND3 Antibody (N-term) (Cat. #AP14226a) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the KCND3 antibody detected the KCND3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UK17
Other Accession Q62897, Q9Z0V1, NP_751948.1, NP_004971.2
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 73451 Da
Antigen Region 13-41 aa
Additional Information
Gene ID 3752
Other Names Potassium voltage-gated channel subfamily D member 3, Voltage-gated potassium channel subunit Kv43, KCND3
Target/Specificity This KCND3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-41 amino acids from the N-terminal region of human KCND3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKCND3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCND3
Function Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Cell projection, dendrite
Tissue Location Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas.
Research Areas
Citations (0)

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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq].


Lundby, A., et al. Br. J. Pharmacol. 160(8):2028-2044(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Liang, P., et al. Biophys. J. 98(12):2867-2876(2010)
Cotella, D., et al. Pflugers Arch. 460(1):87-97(2010)
Tan, X.Q., et al. Zhonghua Xin Xue Guan Bing Za Zhi 37(6):509-513(2009)

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Cat# AP14226a
(40 western blots)
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