|Application ||WB, E|
|Other Accession||Q62897, Q9Z0V1, NP_751948.1, NP_004971.2|
|Calculated MW||73451 Da|
|Antigen Region||13-41 aa|
|Other Names||Potassium voltage-gated channel subfamily D member 3, Voltage-gated potassium channel subunit Kv43, KCND3|
|Target/Specificity||This KCND3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-41 amino acids from the N-terminal region of human KCND3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCND3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Cell projection, dendrite|
|Tissue Location||Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq].
Lundby, A., et al. Br. J. Pharmacol. 160(8):2028-2044(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Liang, P., et al. Biophys. J. 98(12):2867-2876(2010)
Cotella, D., et al. Pflugers Arch. 460(1):87-97(2010)
Tan, X.Q., et al. Zhonghua Xin Xue Guan Bing Za Zhi 37(6):509-513(2009)
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