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HCN1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HCN1 Antibody (C-term) AP14228b
    HCN1 Antibody (C-term) (Cat. #AP14228b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the HCN1 antibody detected the HCN1 protein (arrow).
  • IHC-P - HCN1 Antibody (C-term) AP14228b
    HCN1 Antibody (C-term) (AP14228b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HCN1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60741
Other Accession O88704, NP_066550.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 98796 Da
Antigen Region 860-889 aa
Additional Information
Gene ID 348980
Other Names Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, Brain cyclic nucleotide-gated channel 1, BCNG-1, HCN1, BCNG1
Target/Specificity This HCN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 860-889 amino acids from the C-terminal region of human HCN1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHCN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HCN1
Synonyms BCNG1
Function Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas.
Research Areas
Citations (0)

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Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.


Odefrey, F., et al. Cancer Res. 70(4):1449-1458(2010)
Laurin, N., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (1), 95-103 (2009) :
Woolcott, C.G., et al. Breast Cancer Res. 11 (1), R10 (2009) :
Laurin, N., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (5), 600-605 (2008) :
Tang, B., et al. Neurobiol. Dis. 29(1):59-70(2008)

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$ 295.00
$ 99.00
Cat# AP14228b
(40 western blots)
Availability: In Stock
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