|Application ||WB, E|
|Other Accession||Q95KI4, NP_071434.2|
|Calculated MW||39513 Da|
|Antigen Region||37-65 aa|
|Other Names||Modulator of apoptosis 1, MAP-1, MAP1, Paraneoplastic antigen Ma4, MOAP1, PNMA4|
|Target/Specificity||This MOAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human MOAP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MOAP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.|
|Tissue Location||Widely expressed, with high levels in heart and brain.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.
Lee, S.S., et al. Exp. Cell Res. 315(7):1313-1325(2009)
Foley, C.J., et al. Mol. Cell. Biol. 28(14):4520-4535(2008)
Fu, N.Y., et al. Proc. Natl. Acad. Sci. U.S.A. 104(24):10051-10056(2007)
Lim, J., et al. Cell 125(4):801-814(2006)
Vos, M.D., et al. J. Biol. Chem. 281(8):4557-4563(2006)
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