|Application ||WB, E|
|Calculated MW||80977 Da|
|Antigen Region||61-90 aa|
|Other Names||Angiogenic factor with G patch and FHA domains 1, Angiogenic factor VG5Q, hVG5Q, G patch domain-containing protein 7, Vasculogenesis gene on 5q protein, AGGF1, GPATC7, GPATCH7, VG5Q|
|Target/Specificity||This AGGF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the N-terminal region of human AGGF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AGGF1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPATC7, GPATCH7, VG5Q|
|Function||Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.|
|Cellular Location||Cytoplasm. Secreted. Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted|
|Tissue Location||Widely expressed. Expressed in endothelial cells, vascular smooth muscle cells and osteoblasts. Expressed in umbilical vein endothelial cells and microvascular endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.
Fan, C., et al. J. Biol. Chem. 284(35):23331-23343(2009)
Hu, Y., et al. Ann. Hum. Genet. 72 (PT 5), 636-643 (2008) :
Gutierrez, S., et al. Am. J. Med. Genet. A 140(24):2832-2833(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Kihiczak, G.G., et al. Int. J. Dermatol. 45(8):883-890(2006)
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