|Application ||WB, E|
|Other Accession||NP_066984.1, NP_612190.1|
|Calculated MW||59765 Da|
|Antigen Region||504-532 aa|
|Other Names||Potassium channel subfamily K member 10, Outward rectifying potassium channel protein TREK-2, TREK-2 K(+) channel subunit, KCNK10, TREK2|
|Target/Specificity||This KCNK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 504-532 amino acids from the C-terminal region of human KCNK10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNK10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq].
Gierten, J., et al. Br. J. Pharmacol. 154(8):1680-1690(2008)
Huang, D., et al. Med. Hypotheses 70(3):618-624(2008)
Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005)
Gu, W., et al. J. Physiol. (Lond.) 539 (PT 3), 657-668 (2002) :
Goldstein, S.A., et al. Nat. Rev. Neurosci. 2(3):175-184(2001)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.