|Application ||WB, E|
|Other Accession||NP_066984.1, NP_612190.1|
|Calculated MW||59765 Da|
|Antigen Region||504-532 aa|
|Other Names||Potassium channel subfamily K member 10, Outward rectifying potassium channel protein TREK-2, TREK-2 K(+) channel subunit, KCNK10, TREK2|
|Target/Specificity||This KCNK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 504-532 amino acids from the C-terminal region of human KCNK10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNK10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq].
Gierten, J., et al. Br. J. Pharmacol. 154(8):1680-1690(2008)
Huang, D., et al. Med. Hypotheses 70(3):618-624(2008)
Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005)
Gu, W., et al. J. Physiol. (Lond.) 539 (PT 3), 657-668 (2002) :
Goldstein, S.A., et al. Nat. Rev. Neurosci. 2(3):175-184(2001)
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