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KCNK10 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P57789 |
| Other Accession | NP_066984.1, NP_612190.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59765 Da |
| Antigen Region | 504-532 aa |
| Gene ID | 54207 |
|---|---|
| Other Names | Potassium channel subfamily K member 10, Outward rectifying potassium channel protein TREK-2, TREK-2 K(+) channel subunit, KCNK10, TREK2 |
| Target/Specificity | This KCNK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 504-532 amino acids from the C-terminal region of human KCNK10. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KCNK10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNK10 |
|---|---|
| Synonyms | TREK2 |
| Function | Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq].
References
Gierten, J., et al. Br. J. Pharmacol. 154(8):1680-1690(2008)
Huang, D., et al. Med. Hypotheses 70(3):618-624(2008)
Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005)
Gu, W., et al. J. Physiol. (Lond.) 539 (PT 3), 657-668 (2002) :
Goldstein, S.A., et al. Nat. Rev. Neurosci. 2(3):175-184(2001)
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