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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Mark1 Antibody (C-term)   

Mouse Mark1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Mark1 Antibody (C-term) AP14269B
    Mouse Mark1 Antibody (C-term) (Cat. #AP14269b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Mark1 antibody detected the Mark1 protein (arrow).
  • WB - Mouse Mark1 Antibody (C-term) AP14269B
    Mouse Mark1 Antibody (C-term) (Cat. #AP14269b) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Mark1 antibody detected the Mark1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8VHJ5
Other Accession O08678, NP_663490.2
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 88335 Da
Antigen Region 600-627 aa
Additional Information
Gene ID 226778
Other Names Serine/threonine-protein kinase MARK1, ELKL motif serine/threonine-protein kinase 3, MAP/microtubule affinity-regulating kinase 1, PAR1 homolog c, Par-1c, mPar-1c, Mark1 {ECO:0000312|MGI:MGI:2664902}
Target/Specificity This Mouse Mark1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 600-627 amino acids from the C-terminal region of mouse Mark1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Mark1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mark1 {ECO:0000312|MGI:MGI:2664902}
Function Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (By similarity).
Cellular Location Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Appears to localize to an intracellular network.
Research Areas
Citations (0)

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Mark1 may play a role in cytoskeletal stability (By similarity).


Maussion, G., et al. Hum. Mol. Genet. 17(16):2541-2551(2008)
Hezel, A.F., et al. Mol. Cell. Biol. 28(7):2414-2425(2008)
Trinidad, J.C., et al. Mol. Cell Proteomics 5(5):914-922(2006)
Kerns, R.T., et al. J. Neurosci. 25(9):2255-2266(2005)
Okazaki, N., et al. DNA Res. 11(3):205-218(2004)

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$ 295.00
$ 99.00
Cat# AP14269B
(40 western blots)
Availability: In Stock
Bulk Size
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