Mouse Mark3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q03141 |
Other Accession | P27448, NP_067491.2, NP_073712.2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 84390 Da |
Antigen Region | 608-636 aa |
Gene ID | 17169 |
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Other Names | MAP/microtubule affinity-regulating kinase 3, ELKL motif kinase 2, EMK-2, MPK-10, Mark3, Emk2, Mpk10 |
Target/Specificity | This Mouse Mark3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 608-636 amino acids from the C-terminal region of mouse Mark3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Mark3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Mark3 |
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Synonyms | Emk2, Mpk10 |
Function | Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1. |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P27448}; Peripheral membrane protein {ECO:0000250|UniProtKB:P27448}. Cell projection, dendrite {ECO:0000250|UniProtKB:P27448}. Cytoplasm {ECO:0000250|UniProtKB:P27448} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C (By similarity).
References
Lennerz, J.K., et al. Mol. Cell. Biol. 30(21):5043-5056(2010)
Schwarz, T., et al. Biochem. Biophys. Res. Commun. 394(4):890-895(2010)
Hezel, A.F., et al. Mol. Cell. Biol. 28(7):2414-2425(2008)
Wang, C., et al. Acta Pharmacol. Sin. 28(3):334-338(2007)
Tochio, N., et al. Protein Sci. 15(11):2534-2543(2006)
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