|Application ||WB, E|
|Other Accession||P27448, NP_067491.2, NP_073712.2|
|Calculated MW||84390 Da|
|Antigen Region||608-636 aa|
|Other Names||MAP/microtubule affinity-regulating kinase 3, ELKL motif kinase 2, EMK-2, MPK-10, Mark3, Emk2, Mpk10|
|Target/Specificity||This Mouse Mark3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 608-636 amino acids from the C-terminal region of mouse Mark3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Mark3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C (By similarity).
Lennerz, J.K., et al. Mol. Cell. Biol. 30(21):5043-5056(2010)
Schwarz, T., et al. Biochem. Biophys. Res. Commun. 394(4):890-895(2010)
Hezel, A.F., et al. Mol. Cell. Biol. 28(7):2414-2425(2008)
Wang, C., et al. Acta Pharmacol. Sin. 28(3):334-338(2007)
Tochio, N., et al. Protein Sci. 15(11):2534-2543(2006)
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