Mouse Nek4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9Z1J2 |
Other Accession | P51957, NP_035979.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 88994 Da |
Antigen Region | 74-101 aa |
Gene ID | 23955 |
---|---|
Other Names | Serine/threonine-protein kinase Nek4, Never in mitosis A-related kinase 4, NimA-related protein kinase 4, Serine/threonine-protein kinase 2, Nek4, Stk2 |
Target/Specificity | This Mouse Nek4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-101 amino acids from the N-terminal region of mouse Nek4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Nek4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Nek4 |
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Synonyms | Stk2 |
Function | Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage (By similarity). Protein kinase that seems to act exclusively upon threonine residues. |
Cellular Location | Cytoplasm. Cell projection, cilium {ECO:0000250|UniProtKB:P51957} |
Tissue Location | Expressed ubiquitously among various organs and is up-regulated in the testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Nek4 seems to act exclusively upon threonine residues.
References
Doles, J., et al. Cancer Res. 70(3):1033-1041(2010)
Forrest, A.R., et al. Genome Res. 13 (6B), 1366-1375 (2003) :
Hayashi, K., et al. Biochem. Biophys. Res. Commun. 264(2):449-456(1999)
Chen, A., et al. Gene 234(1):127-137(1999)
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