Mouse Plk5 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q4FZD7 |
Other Accession | NP_898975.2 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 66055 Da |
Antigen Region | 4-31 aa |
Gene ID | 216166 |
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Other Names | Inactive serine/threonine-protein kinase PLK5, Polo-like kinase 5, PLK-5, Plk5 {ECO:0000250|UniProtKB:Q64702} |
Target/Specificity | This Mouse Plk5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-31 amino acids from the N-terminal region of mouse Plk5. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Plk5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Plk5 {ECO:0000250|UniProtKB:Q64702} |
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Function | Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation. |
Cellular Location | Nucleus, nucleolus. Cytoplasm |
Tissue Location | Expressed in the cerebellum, eye and brain cortex (at protein level). Expressed in highly differentiated tissues, such as brain, eyes and ovary. Not detectable in proliferating tissues, such as the colon, spleen and placenta |
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Provided below are standard protocols that you may find useful for product applications.
Background
PLK5 (Serine/threonine-protein kinase PLK5) belongs to the protein kinase superfamily and Ser/Thr protein kinase family and CDC5/Polo subfamily. PLK5P contains 1 POLO box domain and 1 Serine/Threonine protein kinase catalytic domain.
References
Pereira, J.D., et al. Proc. Natl. Acad. Sci. U.S.A. 107(36):15957-15962(2010)
Andrysik, Z., et al. Nucleic Acids Res. 38(9):2931-2943(2010)
Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) :
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