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Mouse Tp53rk Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Tp53rk Antibody (Center) AP14294c
    Mouse Tp53rk Antibody (Center) (Cat. #AP14294c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the Tp53rk antibody detected the Tp53rk protein (arrow).
    detail
  • WB - Mouse Tp53rk Antibody (Center) AP14294c
    Western blot analysis of Tp53rk (arrow) using rabbit polyclonal Mouse Tp53rk Antibody (Center) (Cat. #AP14294c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Tp53rk gene.
    detail
  • WB - Mouse Tp53rk Antibody (Center) AP14294c
    Mouse Tp53rk Antibody (Center) (Cat. #AP14294c) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Tp53rk antibody detected the Tp53rk protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q99PW4
Other Accession NP_076304.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 27394 Da
Antigen Region 100-128 aa
Additional Information
Other Names TP53-regulating kinase, Atypical serine/threonine protein kinase Tp53rk, EKC/KEOPS complex subunit Tp53rk, 36--, Nori-2, p53-related protein kinase, Tp53rk, Prpk, Trp53rk
Target/Specificity This Mouse Tp53rk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-128 amino acids from the Central region of mouse Tp53rk.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Tp53rk Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tp53rkb {ECO:0000305}
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q96S44}.
Research Areas
Citations (0)
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Background

Tp53rk is a protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity).

References

Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) :
Abe, Y., et al. J. Biol. Chem. 276(47):44003-44011(2001)

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$ 365.00
$ 140.00
Cat# AP14294c
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