|Application ||WB, E|
|Calculated MW||27394 Da|
|Antigen Region||100-128 aa|
|Other Names||TP53-regulating kinase, Atypical serine/threonine protein kinase Tp53rk, EKC/KEOPS complex subunit Tp53rk, 36--, Nori-2, p53-related protein kinase, Tp53rk, Prpk, Trp53rk|
|Target/Specificity||This Mouse Tp53rk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-128 amino acids from the Central region of mouse Tp53rk.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Tp53rk Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Tp53rk is a protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity).
Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) :
Abe, Y., et al. J. Biol. Chem. 276(47):44003-44011(2001)
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