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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Tp53rk Antibody (Center)   

Mouse Tp53rk Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Tp53rk Antibody (Center) AP14294c
    Mouse Tp53rk Antibody (Center) (Cat. #AP14294c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the Tp53rk antibody detected the Tp53rk protein (arrow).
  • WB - Mouse Tp53rk Antibody (Center) AP14294c
    Western blot analysis of Tp53rk (arrow) using rabbit polyclonal Mouse Tp53rk Antibody (Center) (Cat. #AP14294c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Tp53rk gene.
  • WB - Mouse Tp53rk Antibody (Center) AP14294c
    Mouse Tp53rk Antibody (Center) (Cat. #AP14294c) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Tp53rk antibody detected the Tp53rk protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q99PW4
Other Accession NP_076304.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 27394 Da
Antigen Region 100-128 aa
Additional Information
Other Names TP53-regulating kinase, Atypical serine/threonine protein kinase Tp53rk, EKC/KEOPS complex subunit Tp53rk, 36--, Nori-2, p53-related protein kinase, Tp53rk, Prpk, Trp53rk
Target/Specificity This Mouse Tp53rk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-128 amino acids from the Central region of mouse Tp53rk.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Tp53rk Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tp53rk
Synonyms Prpk, Trp53rk
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Tp53rk is a protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity).

References

Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) :
Abe, Y., et al. J. Biol. Chem. 276(47):44003-44011(2001)

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$ 295.00
$ 99.00
Cat# AP14294c
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Quantity:
(40 western blots)
Availability: In Stock
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