PITX2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IF, E |
---|---|
Primary Accession | Q99697 |
Other Accession | Q9I8K3, Q6QU75, Q9PWR3, Q9R0W1, P97474, Q9W5Z2, O93385 |
Reactivity | Human |
Predicted | Chicken, Zebrafish, Mouse, Rat, Xenopus |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 35370 Da |
Antigen Region | 122-151 aa |
Gene ID | 5308 |
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Other Names | Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin, PITX2, ARP1, RGS, RIEG, RIEG1 |
Target/Specificity | This PITX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids of human PITX2. |
Dilution | IF~~1:10~50 WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PITX2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PITX2 (HGNC:9005) |
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Function | May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. |
Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:P97474} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.
References
Engenheiro,E., Clin. Genet. 72 (5), 464-470 (2007)
Gudbjartsson,D.F., Nature 448 (7151), 353-357 (2007)
Lowry,R.B., Am. J. Med. Genet. A 143 (11), 1227-1230 (2007)
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