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TEAD3 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TEAD3 Antibody (N-term) AP14305a
    TEAD3 Antibody (N-term) (Cat. #AP14305a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TEAD3 antibody detected the TEAD3 protein (arrow).
    detail
  • IHC-P - TEAD3 Antibody (N-term) AP14305a
    TEAD3 Antibody (N-term) (AP14305a)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TEAD3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q99594
Other Accession P70210, NP_003205.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 48676 Da
Antigen Region 82-110 aa
Additional Information
Gene ID 7005
Other Names Transcriptional enhancer factor TEF-5, DTEF-1, TEA domain family member 3, TEAD-3, TEAD3, TEAD5, TEF5
Target/Specificity This TEAD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-110 amino acids from the N-terminal region of human TEAD3.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTEAD3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TEAD3
Synonyms TEAD5, TEF5
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
Cellular Location Nucleus.
Tissue Location Preferentially expressed in the placenta.
Research Areas
Citations (0)
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Background

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq].

References

Zhang, H., et al. J. Biol. Chem. 284(20):13355-13362(2009)
Zhao, B., et al. Genes Dev. 22(14):1962-1971(2008)
Peng, L., et al. Mol. Endocrinol. 18(8):2049-2060(2004)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Maeda, T., et al. J. Biol. Chem. 277(27):24346-24352(2002)

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$ 182.50
$ 70.00
Cat# AP14305a
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