|Application ||WB, IHC-P, E|
|Other Accession||P70210, NP_003205.2|
|Calculated MW||48676 Da|
|Antigen Region||82-110 aa|
|Other Names||Transcriptional enhancer factor TEF-5, DTEF-1, TEA domain family member 3, TEAD-3, TEAD3, TEAD5, TEF5|
|Target/Specificity||This TEAD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-110 amino acids from the N-terminal region of human TEAD3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TEAD3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.|
|Tissue Location||Preferentially expressed in the placenta.|
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Provided below are standard protocols that you may find useful for product applications.
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq].
Zhang, H., et al. J. Biol. Chem. 284(20):13355-13362(2009)
Zhao, B., et al. Genes Dev. 22(14):1962-1971(2008)
Peng, L., et al. Mol. Endocrinol. 18(8):2049-2060(2004)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Maeda, T., et al. J. Biol. Chem. 277(27):24346-24352(2002)
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