|Application ||WB, IHC-P, E|
|Other Accession||Q63430, Q91YQ3, NP_055275.1|
|Calculated MW||16786 Da|
|Antigen Region||76-105 aa|
|Other Names||Cold shock domain-containing protein C2, RNA-binding protein PIPPin, CSDC2, PIPPIN|
|Target/Specificity||This PIPPIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the Central region of human PIPPIN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIPPIN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=PIPPin-RNA complexes are located to the nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity).
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Schafer, C., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 285 (4), G726-G734 (2003) :
Raimondi, L., et al. J. Cell. Mol. Med. 7(1):35-42(2003)
Nastasi, T., et al. Neuroreport 11(10):2233-2236(2000)
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