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BGLAP Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - BGLAP Antibody (Center) AP14337c
    BGLAP Antibody (Center) (Cat. #AP14337c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the BGLAP antibody detected the BGLAP protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P02818
Other Accession NP_954642.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 10963 Da
Antigen Region 23-52 aa
Additional Information
Gene ID 632
Other Names Osteocalcin, Bone Gla protein, BGP, Gamma-carboxyglutamic acid-containing protein, BGLAP
Target/Specificity This BGLAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-52 amino acids from the Central region of human BGLAP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBGLAP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BGLAP
Function Bone protein that constitutes 1-2% of the total bone protein, and which acts as a negative regulator of bone formation (PubMed:3019668, PubMed:6967872). Functions to limit bone formation without impairing bone resorption or mineralization (By similarity). It binds strongly to apatite and calcium (PubMed:6967872).
Cellular Location Secreted.
Research Areas
Citations (0)
citation

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Background

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

References

Yeap, B.B., et al. Eur. J. Endocrinol. 163(2):265-272(2010)
Lee, Y.J., et al. Diabetes Care 33 (7), E90 (2010) :
Foresta, C., et al. J. Clin. Endocrinol. Metab. 95(7):3502-3506(2010)
Saleem, U., et al. Arterioscler. Thromb. Vasc. Biol. 30(7):1474-1478(2010)
Das, S.K., et al. Dis. Markers 28(5):281-286(2010)

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$ 182.50
$ 70.00
Cat# AP14337c
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