|Application ||WB, E|
|Other Accession||Q9R216, NP_003499.1|
|Calculated MW||64466 Da|
|Antigen Region||7-35 aa|
|Other Names||Frizzled-9, Fz-9, hFz9, FzE6, CD349, FZD9, FZD3|
|Target/Specificity||This FZD9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-35 amino acids from the N-terminal region of human FZD9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FZD9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.
Trubiani, O., et al. J. Cell. Physiol. 225(1):123-131(2010)
Saus, E., et al. J Psychiatr Res (2010) In press :
Fujimoto, T., et al. Int. J. Oncol. 35(4):861-866(2009)
Kim, J.G., et al. J. Korean Med. Sci. 24(3):443-447(2009)
Wang, H.X., et al. Mol. Hum. Reprod. 15(1):11-17(2009)
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