|Application ||WB, E|
|Other Accession||NP_001165439.1, NP_068743.2|
|Calculated MW||88223 Da|
|Antigen Region||131-160 aa|
|Other Names||Cadherin-related family member 5, Mu-protocadherin, Mucin and cadherin-like protein, CDHR5, MUCDHL, MUPCDH|
|Target/Specificity||This MUPCDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-160 amino acids from the N-terminal region of human MUPCDH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MUPCDH Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.|
|Cellular Location||Apical cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein|
|Tissue Location||Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver (PubMed:12167596). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409)|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Goldberg, M., et al. Hum. Genet. 112(4):334-342(2003)
Goldberg, M., et al. Am. J. Physiol. Renal Physiol. 283 (3), F454-F463 (2002) :
Paris, M.J., et al. Genomics 69(2):196-202(2000)
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