TDO2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P48775 |
Other Accession | NP_005642.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 47872 Da |
Antigen Region | 1-30 aa |
Gene ID | 6999 |
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Other Names | Tryptophan 2, 3-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03020}, TDO {ECO:0000255|HAMAP-Rule:MF_03020}, 1131111 {ECO:0000255|HAMAP-Rule:MF_03020}, Tryptamin 2, 3-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03020}, Tryptophan oxygenase {ECO:0000255|HAMAP-Rule:MF_03020}, TO {ECO:0000255|HAMAP-Rule:MF_03020}, TRPO {ECO:0000255|HAMAP-Rule:MF_03020}, Tryptophan pyrrolase {ECO:0000255|HAMAP-Rule:MF_03020}, Tryptophanase {ECO:0000255|HAMAP-Rule:MF_03020}, TDO2 {ECO:0000255|HAMAP-Rule:MF_03020}, TDO |
Target/Specificity | This TDO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TDO2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TDO2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TDO2 {ECO:0000255|HAMAP-Rule:MF_03020} |
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Synonyms | TDO |
Function | Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tryptophan 2,3-dioxygenase (EC 1.13.11.11) plays a role in catalyzing the first and rat-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.[supplied by OMIM].
References
Capece, L., et al. J. Biol. Inorg. Chem. 15(6):811-823(2010)
Schmidt, S.K., et al. Eur. J. Immunol. 39(10):2755-2764(2009)
Roeske, D., et al. Mol. Psychiatry (2009) In press :
Miller, C.L., et al. Schizophr. Res. 113 (2-3), 259-267 (2009) :
Fukumura, E., et al. J. Biochem. 145(4):505-515(2009)
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