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BIN1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BIN1 Antibody (Center) AP14348c
    BIN1 Antibody (Center) (Cat. #AP14348c) western blot analysis in L929 cell line lysates (35ug/lane).This demonstrates the BIN1 antibody detected the BIN1 protein (arrow).
  • WB - BIN1 Antibody (Center) AP14348c
    BIN1 Antibody (Center) (Cat. #AP14348c) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the BIN1 antibody detected the BIN1 protein (arrow).
  • IHC-P - BIN1 Antibody (Center) AP14348c
    BIN1 Antibody (Center) (Cat. #AP14348c)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BIN1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00499
Other Accession O08839, O08539, NP_647595.1, NP_647594.1, NP_004296.1
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 64699 Da
Antigen Region 360-389 aa
Additional Information
Gene ID 274
Other Names Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, BIN1, AMPHL
Target/Specificity This BIN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-389 amino acids from the Central region of human BIN1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBIN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BIN1
Synonyms AMPHL
Function May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
Cellular Location Isoform BIN1: Nucleus.
Tissue Location Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
Research Areas
Citations (0)

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This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.


Biffi, A., et al. Arch. Neurol. 67(6):677-685(2010) Seshadri, S., et al. JAMA 303(18):1832-1840(2010) Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010) Claeys, K.G., et al. Neurology 74(6):519-521(2010) Hong, T.T., et al. PLoS Biol. 8 (2), E1000312 (2010) :

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$ 295.00
$ 99.00
Cat# AP14348c
(40 western blots)
Availability: In Stock
Bulk Size
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