|Application ||WB, E|
|Other Accession||P62916, P62915, Q4R3J5, Q2KIN8, NP_001505.1|
|Predicted||Bovine, Monkey, Rat|
|Calculated MW||34833 Da|
|Antigen Region||42-71 aa|
|Other Names||Transcription initiation factor IIB, General transcription factor TFIIB, S300-II, GTF2B, TF2B, TFIIB|
|Target/Specificity||This GTF2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-71 amino acids from the N-terminal region of human GTF2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GTF2B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II.
Wang, Y., et al. Curr. Biol. 20(6):548-553(2010)
Thompson, N.E., et al. J. Biol. Chem. 284(37):24754-24766(2009)
Gilman, B., et al. J. Biol. Chem. 284(14):9093-9098(2009)
Vogt, C., et al. J. Virol. 82(22):11446-11453(2008)
Elsby, L.M., et al. EMBO Rep. 7(9):898-903(2006)
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