|Application ||WB, E|
|Other Accession||P35478, P25417, NP_000091.1, Q10994|
|Calculated MW||11140 Da|
|Antigen Region||10-39 aa|
|Other Names||Cystatin-B, CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB, CST6, STFB|
|Target/Specificity||This CSTB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the Central region of human CSTB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CSTB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.|
|Cellular Location||Cytoplasm. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ceru, S., et al. J. Biol. Chem. 285(13):10078-10086(2010)
Skerget, K., et al. J. Biol. Chem. 285(5):3201-3210(2010)
Ceru, S., et al. Biol. Cell 102(6):319-334(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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