|Application ||WB, E|
|Other Accession||Q64213, NP_001171502.1, NP_001171501.1, NP_973724.1|
|Calculated MW||68330 Da|
|Antigen Region||212-241 aa|
|Other Names||Splicing factor 1, Mammalian branch point-binding protein, BBP, mBBP, Transcription factor ZFM1, Zinc finger gene in MEN1 locus, Zinc finger protein 162, SF1, ZFM1, ZNF162|
|Target/Specificity||This SF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-241 amino acids from the Central region of human SF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SF1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.|
|Tissue Location||Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence and is required for the early stages of spliceosome assembly. Alternate splicing results in multiple transcript variants.
Jeyabalan, J., et al. PLoS ONE 5 (5), E10646 (2010) :
Corsini, L., et al. J. Biol. Chem. 284(1):630-639(2009)
Rino, J., et al. Mol. Cell. Biol. 28(9):3045-3057(2008)
Olejnik-Schmidt, A.K., et al. Arch. Virol. 153(5):983-990(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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