|Application ||WB, E|
|Calculated MW||30759 Da|
|Antigen Region||50-79 aa|
|Other Names||Interleukin-33, IL-33, Interleukin-1 family member 11, IL-1F11, Nuclear factor from high endothelial venules, NF-HEV, Interleukin-33 (95-270), Interleukin-33 (99-270), Interleukin-33 (109-270), IL33, C9orf26, IL1F11, NFHEV|
|Target/Specificity||This IL33 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human IL33.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL33 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C9orf26, IL1F11, NFHEV|
|Function||Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).|
|Cellular Location||Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent|
|Tissue Location||Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta|
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Provided below are standard protocols that you may find useful for product applications.
Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T helper type 2-associated cytokines.
Yagami, A., et al. J. Immunol. 185(10):5743-5750(2010)
Masamune, A., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (4), G821-G832 (2010) :
Melen, E., et al. J. Allergy Clin. Immunol. 126(3):631-637(2010)
Corneveaux, J.J., et al. Hum. Mol. Genet. 19(16):3295-3301(2010)
Yu, J.T., et al. Neurobiol. Aging (2010) In press :
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